The PlA1/PlA2 polymorphism lies within the gene for your ?three (GPIIIa) subunit of ?IIb?three (GPIIb-IIIa). This integrin serves as a receptor for adhesive proteins fibrinogen and von Willebrand issue and is particularly significant for that cohesive Attributes of platelets. Recognition of these proteins as soluble ligands demands ?IIb?three being